Toxicology and Pharmacology

Biography

Biography: Alexandru Octavian Doma

Abstract

Statement of the Problem: Diabetes mellitus is a chronic disease that is characterized by a relative or absolute lack of insulin, resulting in hyperglycaemia, being one of the most frequent diseases. The purpose of this study was to determine the hypoglycemic effect of some plats extract on Streptozotocin induced diabetes in mice. Methodology: The study was conducted on 35 BALB/c mice divided in five groups: C- control group receiving distillated water, DC – diabetic control receiving distillated water, E1 – diabetic mice receiving 10% Arctium lappa extract, E2 - diabetic mice receiving 1% Betula pendula liophilizate extract, E3 - diabetic mice receiving 5% Althaea officinalis extract. The diabetes was induced by i.p. administration of 200 mg/kg bw Streptozotocin is single dose, mice with glycaemia over 150 mg/dl were considered diabetic and those with over 200 mg/dl were considered to have severe diabetes. Findings: In diabetic rats we observed a significantly (p<0.05) increase of body weight comparative to control and also we observed a significant (p<0.05) increase of water consumption in diabetic rats in the firs 24h, followed by a decrease of these possible due to the change in taste especially in E2 group. Administration of plants extract in groups E1, E2 and E3, decreased significantly (p<0.05) the glycaemia comparative to DC group reaching the values to C group. The decrease of glycaemia in groups that received plants extract was graduated started after 24h after exposure until 120h after exposure: E1/DC 72h: -27.52%; E1/DC 120h: -41.02%; E2/DC 72h: -32.58%; E2.DC 120h: -43.07%; E3/DC 72h: -34.83%; E3/DC 120h: -37.43%. Conclusions: Administration of studied plants extract proven to have a good hypoglycaemic effect and could be recommended for the control of glycaemia.