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Akshath S U

Saveetha Medical College and Hospital, India

Title: Hepatoprotective effect of Phyllanthus niruri against the Paracetamol induced liver toxicity in albino rat

Biography

Biography: Akshath S U

Abstract

To investigate the mode of action of phyllanthus niruri as a prophylactic hepato-protective agent against Paracetamol (PCM) induced liver toxicity in albino rats. Five groups of six animals in each group of Wistar rats with a weight of 180-210 gm were the experimental material. Group I was served as normal control, administered sodium CMC for all the eight days. Group II rats were treated only with PCM at a dose of 2.5 gm/kg on 8th day. Group III animals were administered silymarin at a dose of 50 mg/kg for eight days and PCM at a dose of 2.5 gm/kg on 8th day, while Group IV is the treated group which was given P. niruri aqueous extract at a dose of 200 mg/kg followed by PCM of 2.5 gm/kg on 8th day. Group V rats were administered with P. niruri at a dose of 400 mg/kg for eight days and PCM at a dose of 2.5 gm/kg on 8th day. Biochemical, histological and immune-histological (IHC) examinations were performed. Histo-pathological picture is in line with the biochemical parameters and IHC study revealed that P. niruri acts by preventing the increase in NKT cells subsequently blocking FASL, by anti-apoptotic and by increasing regeneration. Phyllanthus niruri aqueous extract at a dose of 400 mg/kg was more effective than at 200 mg and silymarin 100 mg.