Shanmugam Thangapandiyan
Bharathiar University, India
Title: Sulforaphane prospectively rescue Arsenic induced hepatotoxicity and apoptosis through PI3K/Akt/Nrf2 signaling pathway
Biography
Biography: Shanmugam Thangapandiyan
Abstract
The present investigation was intended to assess the defensive capacity of sulforaphane (SFN) against arsenic (As) prompted hepatotoxicity by enactment of PI3K/Akt/Nrf2 interceded flagging pathway. For this reason, male Wistar rats were haphazardly disseminated into 6 gatherings of 8 rats each: control, Arsenic (5mg/kg BW), SFN in addition to Arsenic (20, 40, 80 mg/kg BW; 5mg/kg BW). The arsenic-incited oxidative harm was affirmed by a noteworthy (p<0.05) increment in the levels of ALAD, and in the Arsenic focus and additionally exhaustion in cell reinforcement content. Besides, Arsenic medications essentially (p<0.05) expanded the expert apoptotic marker (Bax) and DNA harm, with diminished Nrf2 protein in charge of liver insurance. Be that as it may, pretreatment with SFN essentially (p<0.05) diminished the levels of ALAD, Arsenic focus, and brought cancer prevention agent proteins into typical levels. This was expert by hindrance of apoptotic markers by means of actuation of PI3K, Akt and Nrf2 interceded flagging pathway as clear from histology, western smudging and PCR procedures. In summary, SFN treatment shield the hepatocytes in Arsenic treated gatherings proposing a version of liver poisonous quality by means of PI3K/Akt intervened Nrf2 flagging pathway.