Toxicology and Pharmacology

Biography

Biography: Heba Handoussa

Abstract

Statement of the Problem: Alzheimer’s disease (AD) and dementia are multifactorial neurodegenerative disorders driven by various pathogenic events with neuroinflammation and oxidative stress. Phenolics are widely known for their different beneficial characteristics, they could be considered as promising therapeutic agents against neurodegenerative diseases.

Aim: The purpose of this study is to evaluate the potential effect of some Egyptian medicinal plants; Bauhinia variegate (Bv) and Egyptian Nutraceuticals; Corchorus olitorius (Co) & Majorana hortensis (Mh) to ameliorate neuroinflammation and amyloidogenesis accompanied by these neurodegenerative diseases.

Methodology & Theoretical Orientation: Several parameters were used to evaluate the phenolic content in these medicinal plants; cognitive impairment via assessment of neurobehavioral tests, neuroinflammation and oxidative stress which are characteristic features of neurodegenerative diseases.

Findings: Bauhinia variegata showed significant improvement in neurobehavioral even with the least dose studied; 50 mg/kg in Y-maze through enhancing mean % alternation by 57.55% and reduction in Aβ42 levels was observed with same dose of 39.89% and increment of superoxide-dismutase level by 80% while Corchorus olitorius & Majorana hortensis significantly improved recognition memory that was shown to be altered in the LPS group and COX-2 inflammatory markers were reduced by (CO) and (Mh) compared to the LPS group proven by immunohistochemistry investigation.

Conclusion & Significance: These findings suggest that phenolics within these medicinal plants may be useful in protection against dementia and neuroinflammation through enhancement of cognition and limiting neurodegeneration and modulating the proinflammatory pathway.

Recommendations: The high edible phenolics intake could be prophylactically protective against several neurodegenerative diseases.