Deepa Yadav
Jiwaji University, India
Title: Mass spectrometric imaging of rhizomes of Curculigo orchioides and their bioactivities
Biography
Biography: Deepa Yadav
Abstract
Statement of the Problem: Medicinal plants provide a wide range of secondary metabolites and play important role in the treatment of serious disorders. Plants facilitate healing that is potent, profound and life affirming. The present study was aimed to determine the secondary metabolites, antibacterial activity and anti-proliferative activity of Curculigo orchioides.
Methodology & Theoretical Orientation: The secondary metabolites of Curculigo orchioides were identiï¬ed by gas chromatography-mass spectrometry (GC-MS). Antibacterial activity was determined against bacterial strains Escherichia coli, Pseudomonas aeruginosa, Streptococcus pyogenes and Staphylococcus aureus and antiproliferative activity was evaluated against hepatocellular carcinoma (HepG2 cell line).
Findings: GC-MS analysis of alcoholic extract revealed the presence of pharmacologically active compounds like d-Lyxo-d-manno-nononic-1,4-lactone; 3',8,8'-Trimethoxy-3-piperidyl-2,2'-binaphthalene-1,1',4,4'-tetrone; 7-Methyl-Z-tetradecen-1-ol acetate; Paromomycin; Geranyl isovalerate; tert-Hexadecanethiol; 1,2-Propanediol, 3-(tetradecyloxy); n-Hexadecanoic acid; 9-Octadecenoic acid, (2-phenyl-1,3-dioxolan-4-yl)methyl ester, trans and 2H-Cyclohepta[b] furan-2-one and 6-[1-(acetyloxy)-3-oxobutyl] -3,3a,4,7,8,8a-hexahydro-7-methyl-3-methylene. Alcoholic extract of Curculigo orchioides showed significant activity against bacterial pathogens and HepG2 cell lines.
Conclusion & Significance: The data obtained from GC-MS can be used to study the therapeutic efficacy of secondary metabolites, while alcoholic extract showed significant antibacterial and anti-proliferative activity.